DSPE PEG Thiol, DSPE-PEG-SH - Names and Identifiers
DSPE PEG Thiol, DSPE-PEG-SH - Physico-chemical Properties
DSPE PEG Thiol, DSPE-PEG-SH - Introduction
DSPE PEG Thiol, DSPE-PEG-SH(DSPE PEG Thiol, DSPE-PEG-SH) is a commonly used phospholipid compound. It is prepared by the displacement of a carbonyl sulfide to the chain end of a phosphatide alcohol ester.
DSPE-PEG-SH have the following properties:
1. Soluble in most organic solvents, including water and organic solvents.
2. It has high hydrophilicity and hydrophobicity, resulting in good biocompatibility in vivo.
3. It is metal-friendly and can chemically react with metal surfaces to prepare PEG-modified gold nanoparticles.
4. In aqueous solution, it can self-assemble to form nanoparticles or micelle structures.
The main uses of DSPE-PEG-SH include:
1. As a surface modifier of nanoparticles, it can improve its biocompatibility and targeting.
2. used in the biomedical field for the preparation of nano drug delivery system.
3. for the preparation of biosensors and biological imaging probes.
The method of preparing DSPE-PEG-SH generally involves the following steps:
1. Synthesis of DSPE(1,2-dipalmitoyl-sn-SJ).
2. Etherification of glycol to thiol group by nucleophilic substitution reaction.
3. The synthesized DSPE-PEG-SH was purified by column chromatography or solvent evaporation.
Regarding safety information, DSPE-PEG-SH is a relatively safe compound. However, as with any other chemical, there is still a need for safe handling when used. It is recommended to wear chemical protective gloves and glasses when using the compound to avoid skin contact and inhalation. At the same time, follow appropriate laboratory specifications and operating procedures for proper storage and disposal of the compound.
Last Update:2024-04-09 21:11:58